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There's Now a Way to Diagnose IBS With a Simple Blood Test. 

ibs-smart measures the levels of two validated IBS biomarkers, anti-CdtB and anti-vinculin. These biomarkers are elevated in a majority of IBS patients with diarrheal symptoms and can diagnose diarrhea-predominant or mixed-type IBS (IBS-D or IBS-M). These biomarkers are not commonly elevated in patients with constipation-predominant IBS (IBS-C). Only a licensed physician can order ibs-smart and diagnose IBS. 

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The validation study for ibs-smart shows that elevated biomarkers indicate IBS with up to 100% positive predictive value. Furthermore, this test is highly specific in distinguishing between IBS and IBD.

Order Online.

No appointment necessary

You can work with a doctor online to order ibs-smart, if it’s right for you.

The online service includes: 

  • A symptoms evaluation by a doctor

  • Clear and actionable results emailed directly to you

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Prefer to work with your healthcare provider instead? Download the ibs-smart discussion guide and educational materials here

What is IBS & What Causes IBS?

Dr. Kapil Gupta explains: ​

  • IBS is a health issue found in your intestines

  • IBS causes persistent abdominal pain, cramping, gas, bloating, and change in stool.

  • Food poisoning is the leading known cause of IBS (60-70% of cases of IBS with diarrhea).

Is ibs-smart Right for You?

Have you been experiencing the following symptoms once or more a week for at least four weeks? 

  • Diarrhea or alternating diarrhea and constipation

  • Stomach pain 

  • Bloating


If you have been experiencing these symptoms, ibs-smart could help you begin the right treatment quickly and prevent years of potentially unnecessary procedures like colonoscopies.

IBS can occur alongside other serious illnesses. Ensure that you have thoroughly discussed all of your symptoms with your doctor to determine whether additional testing is necessary. 


The American College of Gastroenterology's Clinical Guidelines for the Management of IBS suggest "a positive diagnostic strategy" (ruling in IBS) as compared to "a diagnostic strategy of exclusion" (ruling out other diseases) " improve time to initiate appropriate therapy....and to improve cost-effectiveness."

How Do You Test for IBS?

​Dr. Mark Pimentel explains: 

  • IBS has traditionally been diagnosed using multiple tests to exclude the possibility of other diseases. If no other health issues are found, a diagnosis of IBS is made.

  • Scientists have since discovered validated biomarkers for IBS that can be measured with a blood test. These biomarkers are effective in diagnosing (ruling in) the majority of IBS-D and IBS-M cases

If either antibody biomarker is 'Elevated,' your test results can be considered 'Positive.'

If Your ibs-smart Results Are Positive:

You know with certainty that you have IBS.

The organic biomarkers tested by ibs-smart have a positive predictive value of IBS that is 96%-100%. 

You know the cause, which can help personalize treatment.

If the measured biomarkers are elevated, your IBS developed from gastroenteritis (food poisoning). This means your gut microbiome has been disrupted, indicating that treatments that target the gut microbiome could be effective for you. 

Here's how food poisoning leads to IBS.

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Results Interpretation Guide

You could avoid years of additional testing and costs.

If your doctor determines you have no other alarm symptoms, further testing may be unnecessary. 

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This review in Digestive Diseases and Sciences provides an excellent overview of how gastroenteritis (food poisoning) can lead to IBS and discusses various treatment options for post-infectious IBS.

Getting Your Results Is Easy. 

All that's needed is a blood sample. 

The ibs-smart kit includes materials for at-home blood draw, a test order form, and prepaid shipping.

There are two convenient ways to order. 


ibs-smart requires a doctor's signature. You can work with a doctor online, or have your own doctor order ibs-smart for you. 

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