ibs-smart™ is a blood test that detects validated IBS biomarkers, anti-CdtB and anti-vinculin. 

These markers are known to be elevated in a majority of patients with IBS-D or IBS-M and indicate the cause was gastroenteritis

FOOD POISONING TO IBS

What Happens?

INFECTION

All common bacteria that cause food poisoning release Cytolethal Distending Toxin B (CdtB)

IMMUNE RESPONSE

Anti-CdtB antibodies are generated to target the toxin. Because of molecular mimicry, anti-vinculin is produced

AUTOIMMUNITY

Anti-vinculin attacks an important protein in the gut, leading to nerve damage and dysmotility

IBS-D or IBS-M

The result is IBS with a diarrheal component. Symptoms include abdominal pain, bloating and diarrhea.

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A review conducted at the Mayo Clinic of forty studies concluded that 1 in 9 (11%) patients who experience food poisoning develop IBS.  

PATIENTS TO CONSIDER

  • Have IBS symptoms with a diarrheal component

  • Have no alarm symptoms (e.g., Blood in stool)

  • May not remember having had food poisoning

  • May have factors that increase risks associated with invasive procedures

ibs-smart™ has broad applicability to patients with diarrheal symptoms. 

Up to 60% of patients with diarrheal IBS symptoms could be suffering from post-infectious IBS.

 

CLEAR LAB RESULTS

If either antibody is ‘Elevated,’ the test results can be considered positive and the patient can be confidently diagnosed with IBS-D or IBS-M.

If both antibodies are ‘Not Elevated,’ the test results can be considered inconclusive. Further testing may be required in this case.

ibs-smartTM is a Lab Developed Test (LDT) conducted at a CLIA-certified (CAP accredited) Lab.

DOWNLOAD THE ibs-smart™ RESULTS INTERPRETATION GUIDE HERE

With ibs-smart™, you can rule in  IBS using a blood test and determine the original cause.  

As a complement to your diagnostic protocol, ibs-smart™ can help you identify the most appropriate patients for invasive testing.

POST-TEST PROBABILITY OF IBS WITH POSITIVE RESULTS

Up to 98%

SPECIFICITY IN DISTINGUISHING BETWEEN IBS AND IBD

Up to 94%

ibs-smartIS PRICED FOR ACCESSIBILITY

UNCOVERED COST: $220

ibs-smart™ is covered at least in part by many common insurance plans.

The Patient Responsibility for Medicare and Medicaid patients is $0.

 

CPT Code: 83520

Billed once for each antibody

(Anti-CdtB and Anti-vinculin)

A published cost minimization model showed a test like ibs-smart™ could save a health system up to $800 per patient by preventing potentially unnecessary procedures.

All that's needed is a blood sample and signed requisition form.

 

Phlebotomy kits and custom requisition forms are provided at no cost to you.   

Results are available within four days. 

ORDERING ibs-smartIS EASY

Click below

to get started

Canadian prescriber? Click here

A SIMPLE BLOOD TEST

AN ANSWER YOU CAN TRUST

ibs-smart™️ is brought to patients by Gemelli Biotech. 

Learn more about our work, principles and leadership at www.gemellibiotech.com.

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ibs-smart™️ is the only licensed, patented antibody blood test for the diagnosis of IBS. See the full list of patents here

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