One in Nine People Who Experience Food Poisoning Develop IBS
A significant volume of research shows a clear link between food poisoning and irritable bowel syndrome (IBS), especially diarrhea-predominant IBS (IBS-D). A recent review conducted at the Mayo Clinic of over 45 studies showed that one in every nine patients who experience food poisoning develop IBS.
It's important to note IBS can develop many years after the initial infection. Many patients don't remember the original instance of food poisoning that may have led to IBS.
How Exactly Does Food Poisoning Lead to IBS?
It has to do with a toxin called Cytolethal Distending Toxin B, or CdtB for short. It turns out that every one of the most common bacteria that cause food poisoning releases CdtB.
When a toxin like CdtB enters your body, your immune system fights back with an antibody - in this case, anti-CdtB.
Anti-CdtB can confuse your body into developing another antibody called anti-vinculin. This harms a naturally occurring protein in your body called vinculin that helps cells migrate and connect to each other.
This is an autoimmune response and leads to gut nerve damage and improper functioning of the Interstitial Cells of Cajal (ICC) and Migrating Motor Complexes (MMC), which regulate the contractions of your gut.
This can ultimately result in diarrhea-predominant and mixed-type (diarrhea with constipation) irritable bowel syndrome, sometimes many years after the initial infection.
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