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Results 
Interpretation

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IBS Blood Test Results

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If either antibody is "Elevated," the test results can be considered positive and the patient can be confidently diagnosed with IBS-D or IBS-M.

If both antibodies are "Not Elevated," the test results can be considered non-indicative of post-infectious IBS. Further testing may be required in this case.

ibs-smart is a Laboratory Developed Test, conducted at a CLIA-Certified Partner. PacificDx

ibs-smart Results Interpretation Guide

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Anti-CdtB: Elevated | Anti-Vinculin: Not Elevated

Positive for Irritable Bowel Syndrome (IBS)

Specificity 94% | Positive Predictive Value 96%

Understanding the Results: Anti-CdtB Elevated, Anti-vinculin Not Elevated
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  • Suggests recent or past gastroenteritis. 

  • Immune system has responded to CdtB toxin with antibodies.  

  • Studies show that anti-CdtB predicts a disturbed microbiome has occurred after gastroenteritis. 

  • The patient is at higher risk for subsequent infectious enteritis.

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Anti-CdtB: Not Elevated | Anti-Vinculin: Elevated

Positive for Irritable Bowel Syndrome (IBS)

Specificity 91% | Positive Predictive Value 96%

  • Initial gastroenteritis may have occurred a long time ago. 

  • Anti-vinculin, an autoimmune response, has developed and an altered microbiome may be seen. 

  • Elevated anti-vinculin levels may indicate a more severe condition and a greater chronicity of disease. (Anti-vinculin autoimmunity usually develops 3-4 months after the infection.)

  • The patient is at higher risk for subsequent infectious enteritis.