DIAGNOSE IBS 

WITH A SIMPLE 

BLOOD TEST

ibs-smart™ is a blood test that detects validated IBS biomarkers, anti-CdtB and anti-vinculin. 

These markers are known to be elevated in a majority of patients with IBS-D or IBS-M and indicate the cause was gastroenteritis

Anti-CdtB

Anti-vinculin

IBS BIOMARKERS

A 2,500+ patient study conducted at Cedars-Sinai validated anti-CdtB and anti-vinculin as highly specific biomarkers for IBS.  

An assessment of these biomarkers in IBS subtypes showed that they have broad applicability in diagnosing patients with IBS-D or IBS-M (IBS with a diarrheal component).  

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Diagnosing IBS with ibs-smart™

• Validated IBS biomarkers provide a diagnosis of inclusion.

• Antibody blood testing offers an organic confirmation of an IBS diagnosis.

• A positive result indicates the root cause of the patient's IBS was an instance of infectious gastroenteritis. 

Dr. Mark Pimentel​

Professor of Medicine at Geffen School of Medicine and Cedars-Sinai Medical Center in Los Angeles, California.

FOOD POISONING TO IBS

What Happens?

INFECTION

All common bacteria that cause food poisoning release Cytolethal Distending Toxin B (CdtB).

IMMUNE RESPONSE

Anti-CdtB antibodies are generated to target the toxin. Because of molecular mimicry, anti-vinculin is produced.

AUTOIMMUNITY

Anti-vinculin attacks an important protein in the gut, leading to nerve damage and dysmotility.

IBS-D or IBS-M

The result is IBS with a diarrheal component. Symptoms include abdominal pain, bloating, and diarrhea.

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A review conducted at the Mayo Clinic of forty studies concluded that 1 in 9 (11%) patients who experience food poisoning develop IBS.  

With ibs-smart™, you can rule in  IBS using a blood test and determine the original cause.  

As a complement to your diagnostic protocol, ibs-smart™ can help you focus diagnostic workups.

ibs-smart™ is a second-generation test and is the only licensed, patented antibody blood test for IBS. The validation study established that a positive result indicated IBS with a post-test probability of up to 98% and specificity up to 94%. 

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Dr. Mark Pimentel​

Professor of Medicine at Geffen School of Medicine and Cedars-Sinai Medical Center in Los Angeles, California.

Where does ibs-smart™ fit in a diagnostic protocol?

  • ibs-smart™ is an effective complement to your current diagnostic protocol.
     

  • As a first-in-line test, ibs-smart™ helps focus diagnostic work-ups and speeds up the assessment of undiagnosed patients with diarrheal symptoms.
     

  • The test offers the fastest path to an IBS diagnosis, which can help you begin treatment for your patients more quickly.

 

PATIENTS TO CONSIDER

  • Have IBS symptoms with a diarrheal component

  • Have no alarm symptoms (e.g., blood in stool)

  • May or may not remember having had food poisoning

  • May have factors that increase risks associated with invasive procedures

ibs-smart™ has broad applicability to patients with diarrheal symptoms.

Up to 60% of patients with diarrheal IBS symptoms could be suffering from post-infectious IBS.

A review in Digestive Diseases and Sciences on the Microbiome and IBS provided an overview on the pathophysiology of post-infectious IBS along with a discussion on treatment options. 

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CLEAR LAB RESULTS

If either antibody is "Elevated," the test results can be considered positive and the patient can be confidently diagnosed with IBS-D or IBS-M.

If both antibodies are "Not Elevated," the test results can be considered non-indicative of post-infectious IBS. Further testing may be required in this case.

DOWNLOAD THE ibs-smart™ RESULTS INTERPRETATION GUIDE HERE. 

PRICED FOR ACCESSIBILITY

UNCOVERED COST: $220

ibs-smart™ is covered at least in part by many common insurance plans.

The patient responsibility for Medicare and Medicaid patients is $0.

 

CPT Code: 83520

Billed once for each antibody

(Anti-CdtB and Anti-vinculin)

A published cost minimization model showed a test like ibs-smart™ could save a health system up to $800 per patient by preventing potentially unnecessary procedures.

ORDERING ibs-smartIS EASY

All that's needed is a blood sample and signed requisition form.

 

Phlebotomy kits and custom requisition forms are provided at no cost to you.   

Results are available within four days. 

Click below to get started.

THE SIMPLEST PATH

TO AN

IBS DIAGNOSIS

ibs-smart™️ is the only licensed, patented antibody blood test for the diagnosis of IBS. See the full list of patents here

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ibs-smart™️ is brought to patients by Gemelli Biotech. 

Learn more about our work, principles and leadership at www.gemellibiotech.com.

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