RESULTS INTERPRETATION
IBS BLOOD TEST RESULTS
If either antibody is "Elevated," the test results can be considered positive and the patient can be confidently diagnosed with IBS-D or IBS-M.
If both antibodies are "Not Elevated," the test results can be considered non-indicative of post-infectious IBS. Further testing may be required in this case.
ibs-smart™ is a Laboratory Developed Test, conducted at a CLIA-Certified Partner. PacificDx
ibs-smart™ RESULTS INTERPRETATION GUIDE
Anti-CdtB: Elevated | Anti-Vinculin: Not Elevated
Positive for Irritable Bowel Syndrome (IBS)
Specificity 94% | Positive Predictive Value 96%
-
Suggests recent or past gastroenteritis.
-
Immune system has responded to CdtB toxin with antibodies.
-
Studies show that anti-CdtB predicts a disturbed microbiome has occurred after gastroenteritis.
-
The patient is at higher risk for subsequent infectious enteritis.
Anti-CdtB: Not Elevated | Anti-Vinculin: Elevated
Positive for Irritable Bowel Syndrome (IBS)
Specificity 91% | Positive Predictive Value 96%
-
Initial gastroenteritis may have occurred a long time ago.
-
Anti-vinculin, an autoimmune response, has developed and an altered microbiome may be seen.
-
Elevated anti-vinculin levels may indicate a more severe condition and a greater chronicity of disease. (Anti-vinculin autoimmunity usually develops 3-4 months after the infection.)
-
The patient is at higher risk for subsequent infectious enteritis.
Anti-CdtB: Elevated | Anti-Vinculin: Elevated
Positive for Irritable Bowel Syndrome (IBS)
Specificity 100% | Positive Predictive Value 100%
-
An immune response is fighting the toxin with antibodies and fueling creation of anti-vinculin.
-
A recent infection is likely, whether it is the initial infection or a subsequent one.
-
Anti-vinculin, an autoimmune response, has developed and an altered microbiome may be seen.
-
Elevated anti-vinculin levels may indicate a more severe condition and a greater chronicity of disease. (Anti-vinculin autoimmunity usually develops 3-4 months after the infection.)
-
The patient is at higher risk for subsequent infectious enteritis.
Anti-CdtB: Not Elevated | Anti-Vinculin: Not Elevated
Non-Indicative of Post-Infectious IBS
-
Patient could still have IBS, but it may not be post-infectious in nature.
-
Additional testing may help determine another cause for symptoms.
