RESULTS INTERPRETATION
IBS BLOOD TEST RESULTS
If either antibody is ‘Elevated,’ the test results can be considered positive. The patient can be confidently diagnosed with IBS-D or IBS-M.
If both antibodies are ‘Not Elevated,’ the test results can be considered non-indicative of post-infectious IBS. Further testing may be required in this case.
Anti-CdtB: Elevated | Anti-Vinculin: Not Elevated
Positive for Irritable Bowel Syndrome (IBS)
Specificity 94% | Positive Predictive Value 96%
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Suggests recent or past gastroenteritis.
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Immune system has responded to CdtB toxin with antibodies.
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Studies show that anti-CdtB predicts a disturbed microbiome has occurred after gastroenteritis.
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The patient is at higher risk for subsequent infectious enteritis.
Anti-CdtB: Not Elevated | Anti-Vinculin: Elevated
Positive for Irritable Bowel Syndrome (IBS)
Specificity 91% | Positive Predictive Value 96%
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Initial gastroenteritis may have occurred a long time ago.
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Anti-vinculin, an autoimmune response, has developed and an altered microbiome may be seen.
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Elevated anti-vinculin levels may indicate a more severe condition and a greater chronicity of disease. (Anti-vinculin autoimmunity usually develops 3-4 months after the infection.)
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The patient is at higher risk for subsequent infectious enteritis.
Anti-CdtB: Elevated | Anti-Vinculin: Elevated
Positive for Irritable Bowel Syndrome (IBS)
Specificity 100% | Positive Predictive Value 100%
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An immune response is fighting the toxin with antibodies and fueling creation of anti-vinculin.
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A recent infection is likely, whether it is the initial infection or a subsequent one.
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Anti-vinculin, an autoimmune response, has developed and an altered microbiome may be seen.
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Elevated anti-vinculin levels may indicate a more severe condition and a greater chronicity of disease. (Anti-vinculin autoimmunity usually develops 3-4 months after the infection.)
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The patient is at higher risk for subsequent infectious enteritis.
Anti-CdtB: Not Elevated | Anti-Vinculin: Not Elevated
Non-Indicative of Post-Infectious IBS
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Patient could still have IBS, but it may not be post-infectious in nature.
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Additional testing may help determine another cause for symptoms.
