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ibs-smart™ Blood Test

ibs-smart™ blood test

How does the ibs-smart™ test work?
 

ibs-smart™ measures the levels of two antibodies in your blood (anti-CdtB and anti-vinculin) known to be elevated in patients with post-infectious IBS (IBS-D or IBS-M). 

 

ibs-smart™ is the only licensed and patented antibody blood test for IBS.

 

What is the process of getting the ibs-smart™ test?
 

All that’s needed is a blood sample and a doctor’s signature. You can work with your own doctor or use our telehealth service to obtain a test order form. 

 

Once that has been done, you will then be provided with a kit with which to have your blood professionally drawn. 

 

Once the blood has been drawn, your doctor or phlebotomist will send your blood sample to our lab in Irvine, CA. 

 

Your results will be available, either by email or from your ordering doctor, within four days after receiving your sample. 

 

If levels of either antibody are elevated in your blood, you can be diagnosed with IBS-D or IBS-M with up to 100% certainty. 

What does the test measure? 
 

ibs-smart™ measures the levels of two antibodies, anti-CdtB and anti-vinculin, that are known to be elevated in patients with post-infectious IBS.

 

Anti-CdtB is developed from an immune response to the toxin, CdtB, released by the most common bacteria that cause food poisoning. 

 

Anti-vinculin is an autoimmune response against a protein, vinculin, that is critical for healthy gut function. 

 

Elevated levels of either antibody indicate IBS.  

 

Which types of IBS does ibs-smart™ help diagnose?

 

ibs-smart™ is useful in the diagnosis of IBS-D and IBS-M. 

 

However, ibs-smart™ is not useful in the diagnosis of IBS-C, because the antibodies the test measures are not often found to be elevated in patients with IBS-C. 

 

How accurate is ibs-smart™?
 

ibs-smart™ is the only licensed and patented antibody blood test for IBS and is a second-generation test for the measurement of anti-CdtB and anti-vinculin. (citation) 

 

ibs-smart™ has been scientifically validated and is performed in a CLIA-certified laboratory. 

 

Patients with elevated levels of either anti-CdtB or anti-vinculin, as measured by ibs-smart™, can be diagnosed with IBS with 96% certainty (positive predictive value).

 

Patients with elevated levels of both anti-CdtB and anti-vinculin antibodies, as measured by ibs-smart™, can be diagnosed with IBS with 100% certainty (positive predictive value). 


 

How do I know if ibs-smart™ is right for me? 
 

ibs-smart™ may be right for you if:

 

  • You have diarrheal IBS symptoms for four weeks or more, including stomach pain and cramping, bloating, diarrhea, and/or alternating diarrhea and constipation;

 

  • You have no major alarm symptoms (e.g., blood in your stool that has not yet been addressed by your healthcare provider); or

 

  • You would prefer a blood test before undergoing more complex or invasive procedures for your GI symptoms. 

 

 

If I don’t recall having food poisoning, should I still take the test? 

While ibs-smart™ measures antibodies that indicate IBS caused by food poisoning, it is not required that you recall any instances of food poisoning in the past. The instance of food poisoning may have been minor, and/or your IBS symptoms may have developed after a period of being asymptomatic

 

I have IBS-C (constipation). Can I use this test? 

Post-infectious IBS most commonly manifests as IBS with a diarrheal component (IBS-D or IBS-M). It very rarely manifests as constipation-predominant IBS (IBS-C). (Read more.)

 

It is recommended that ibs-smart™ be administered to those with symptoms of IBS-D or IBS-M and not to those with symptoms of IBS-C. 

 

While we generally don't recommend this test for constipation-predominant patients, there are some instances where these antibodies are elevated in patients with IBS-C. 

 

If the levels of anti-CdtB and/or anti-vinculin are elevated, an IBS diagnosis can still be made with 96% -100% certainty and the root cause can still be established as food poisoning. 

 

Does this test diagnose SIBO?

Ibs-smart™ does not diagnose SIBO. ibs-smart™ measures the levels of two antibodies that indicate irritable bowel syndrome to a high degree of certainty. It is estimated that up to 80% of IBS patients have SIBO, so a positive result on ibs-smart™ indicates a high likelihood of SIBO, but does not provide a diagnosis of SIBO. 

 

SIBO is usually diagnosed with a breath test.

 

SIBO is associated with many illnesses in addition to IBS. A breath test can indicate SIBO but does not identify IBS as the associated illness, nor does it identify the root cause. 

 

Patients and prescribers might choose to use both the antibody blood test and a breath test to form a complete picture of the patient’s illness. 

 

 

I am currently on or have been on treatments for my condition (e.g., IGG therapy, antibiotics like Rifaximin). Will this impact the results of the test?

 

At this time, there is no definitive research to indicate the impact of specific treatments on the levels of anti-CdtB and anti-vinculin. Anecdotally, patients on various treatments have used ibs-smart™ and still received useful results. 

 

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ibs-smart™️ is the only licensed, patented antibody blood test for the diagnosis of IBS. See the full list of patents here

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ibs-smart™️ is brought to patients by Gemelli Biotech. 

Learn more about our work, principles and leadership at www.gemellibiotech.com.

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